Polyamines Polyamines as targets for therapeutic intervention. LJ Marton and AE Pegg. Annu Rerv Pharmacol. Toxicol. 35:55-91. 1995. Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines. L Jeffers, D Church, H Basu, L Marton, G Wilding. Cancer Chemother Pharmacol. 40:172-179. 1997. Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo. GP Zagaja, M Shrivastav, MJ Fleig, LJ Marton, CW Rinker-Schaeffer, ME Dolan. Cancer Chemother Pharmacol. 41:505-512. 1998. Induction of DNA topoisomerase II-mediated DNA cleavage by b-lapachone and related naphthoquinones. B. Frydman, LJ Marton, JS Sun, K Neder, DT Witiak, AA Liu, H-M Wang, Y Mao, H-Y Wu, MM Sanders, LF Liu. Cancer Research 57:620-627. FEB. 15, 1997. Concerning the synthesis of 3,7,13,17-tetramethyl-5,15-diphenylporphyrin, a sterically hindered porphyrin. A Valasinas, J Hurst, B. Frydman. JOC 63(4):1239-124. Jan. 22, 1998. Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents. ME Dolan, B Frydman, CB Thompson, AM Diamond, BJ Garbiras, AR Safa, WT Beck, LJ Marton. Anti-Cancer Drugs 9:437-448. 1998. 1,4-diaminobutanes from furans: A new synthetic approach to substituted putrescines. B. Frydman and MI Ojea. Tetrahedron Letters 39:4765-4768. April, 1998. Reaction of ß-Lapachone and related naphthoquinones with 2-mercaptoethanol: A biomimetic model of topoisomerase II poisoning by quinones. K Neder, LJ Marton, LF Liu, and B. Frydman. Cellular and Molecular Biology 44(3):465-474. May 1998. Antiproliferative effects of N1,N4-dibenzylputrescine in human and rodent tumor cells. G. Aizencang, P Harari, G. Buldain, L. Guerra, M. Pickart, P. Hernandez, and B. Frydman. Cellular and Molecular Biology 44(4):615-625. June 1998. Variable-temperature solid-state 15N cross-polarization magic-angle spinning nuclear magnetic resonance analysis of octamethylporphyrin. CO Fernandez, M Kogan, A. Valasinas, B. Frydman. JOC 63(14):4829-4831. June 1998. A preparative synthesis of lapachol and related naphthoquinones. JS Sun, AH Geiser, and B. Frydman. Tetrahedron Letters 39:8221-8224. August 1998. Conformationally restricted analogues of 1N,12N-bisethylspermine: Synthesis and growth inhibitory effects on human tumor cell lines. VK Reddy, A Valasinas, A Sarkar, HS Basu, LJ Marton, and B. Frydman. J Med Chem 41(24):4723-4732. October 1998. Variable-temperature Solid-state 13C- and 15N-CPMAS NMR analyses of alkyl-substituted prophycenes. B Frydman, CO Fernandez and E Vogel. JOC 63(25):9385-9391. November 1998. Polyamine-based chemotherapy of cancer. B Frydman and A Valasinas. Exp. Opin. Ther. Patents 9(8):1055-1068. 1999. Regioselective binding of spermine, N1,N12-bismethylspermine, and N1,N12-bisethylspermine to tRNAPhe as revealed by 750 MHz 1H-NMR and its possible correlation with cell cycling and cytotoxicity. B Frydman, WM Westler, A Valasinas, DL Kramer, and CW Porter. J. Braz. Chem. Soc. 10(4):334-340. 1999. Cis-Unsaturated Analogues of 3,8,13,18,23-Pentaazapentacosane (BE-4-4-4-4): Synthesis and Growth Inhibitory Effects on Human Prostate Cancer Cell Lines. VK Reddy, A Sarkar, A Valasinas, LJ Marton, HS Basu, B Frydman. J. Med Chem. 44:404-417. 2001. Conformationally restricted analogues of 1N,14N-bisethylhomospermine (BE-4-4-4): Synthesis and growth inhibitory effects on human prostate cancer cells. A Valasinas, A Sarkar, V Reddy, LJ Marton, HS Basu, B. Frydman. J. Med. Chem. 44:390-403. 2001. [1N,12N]Bis(Ethyl)-cis-6,7-Dehydrospermine: A new drug for treatment and prevention of Cryptosporidium parvum infection of mice deficient in T-cell receptor Alpha. WR Waters, B Frydman, LJ Marton, A Valasinas, VK Reddy, JA Harp, MJ Wannemuehler, and N Yarlett. Antimicrobial Agents and Chemotherapy. 44(10):2891-2894. 2000. Novel synthetic polyamines are effective in the treatment of experimental Microsporidiosis, an opportunistic AIDS-associated infection. CJ Bacchi, LM Weiss, S Lane, B Frydman, A Valasinas, V Reddy, JS Sun, LJ Marton, IA Khan, M Moretto, N Yarlett, and M Wittner. Antimicrobial Agents and Chemotherapy. 46(1):55-61. 2002. SL-11158, a synthetic oligoamine, inhibits polyamine metabolism of Encephalitozoon cuniculi. CJ Bacchi, D Orozco, LM Weiss, B Frydman, A Valasinas, N Yarlett, LJ Marton, and M Wittner. J. Eukaryot. Microbiol. 92S-94S. 2001. Antizyme induction by polyamine analogues as a factor in cell growth inhibition. JLA Mitchell, A Leyser, MS Holtorff, JS Bates, B Frydman, VK Reddy and LJ Marton. Biochem J. 366(2):663-672. 2002. A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice. B Frydman, CW Porter, Y Maxuitenko, A Sarkar, S Bhattacharya, A Valasinas, VK Reddy, N Kisiel, LJ Marton, and HS Basu, Ca Chemother and Pharm. In Press. Published on line April 15, 2003. A novel polyamine analogue inhibits growth and induces apoptosis in human breast cancer cells. Y Huang, ER Hager, DL Phillips, VR Dunn, A Hacker, B Frydman, AL Valasinas, VK Reddy, LJ Marton, RA Casero Jr, NE Davidson. Clin. Ca Rsch. In Press. 2003. Prostate-specific antigen: a diagnostic marker and a tool for targeted delivery of drugs to prostate tumours. B Frydman and HS Basu. Expert Opin. Ther. Patents. 12(7):1035-1046. 2002. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Y. Wang, T. Murray-Stewart, W. Devereux, A. Hacker, B. Frydman, P.M. Woster, R.A. Casero Jr. Biochem. Biophys. Rsch Comm. 304:605-611 (2003). Long Chain Polyamines (Oligoamines) Exhibit Strong Cytotoxicities Against Human Prostate Cancer Cells. H.S. Basu, A. Valasinas, A. Sarkar, V.K. Reddy, A.V. Blokhin, S. Bhattacharya, L.J. Marton, and B. Frydman. Bioorg. Med. Chem. (2003) in press. Cyclopropane Containing Polyamine Analogs are Efficient Growth Inhibitors of Human Prostate Tumor Xenografts in Nude Mice. B. Frydman, A.V. Blokhin, S. Brummel, G. Wilding, Y. Maxuitenko, A. Sarkar, S. Bhattacharya, D. Church, V.K. Reddy, J.A. Kink, L.J. Marton, A. Valasinas, and H.S. Basu. J. Med. Chem. In Press. 2003. Sequential Pathogenesis Pulliam L, Tang NM, Herndier BG and McGrath MS. HIV-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest 87:503-512; 1991. McGrath MS, Shiramizu B, Meeker T, Kaplan L and Herndier B. AIDS-associated polyclonal lymphoma: Identification of a new HIV-associated disease process. JAIDS 4(4):408-415; 1991. 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JAIDS 8:379-385; 1995. Kaplan LD, Shiramizu B, Herndier B, Hahan J, Meeker TC, Ng V, Volberding PA, and McGrath MS. Influence of molecular characteristics on clinical outcome in HIV-associated non-Hodgkin's lymphoma: Identification of a subgroup with favorable clinical outcome. Blood 85:1727-1735; 1995. McGrath MS. Pathogenesis of AIDS-associated lymphoma. Leukemia, 10(6):1077-1078; 1996. Komanduri KV, Luce JA, McGrath MS, Herndier BG, Ng VL. The natural history and molecular heterogeneity of HIV-associated primary malignant lymphomatous effusions. JAIDS, 13:215-226; 1996. Pulliam L, Clarke JA, McGrath MS, Moore D, McGuire D. Monokine products as predictors of AIDS dementia. AIDS 10:1495-1500; 1996. Pulliam L, Gascon R, Stubblebine M, McGuire D, McGrath MS. Unique monocyte subset in patients with AIDS dementia. Lancet 349:692-695; 1997. Ng V, Hurt M, Herndier B, Fry KE, McGrath MS. VH gene used by HIV-1 associated lymphoproliferations. AIDS Res & Hum Retro, 13(2):135-149; 1997. Mack KD, Wei R, McGrath MS. A novel method for DEAE-dextran mediated DNA transfection of primary cultured human macrophages. J Immun Methods 211:79-86, 1998. Ng V, McGrath MS. The immunology of AIDS-associated lymphomas. Immunological Reviews 162:293-298; 1998. McGrath MS, Kodelja V. Balanced macrophage activation hypothesis: A biological model for development of drugs targeted at macrophage functional states. Pathobiology 67:277-281; 1999. Holly EA, Lele C, Bracci PM, McGrath MS. Case-control study of non-Hodgkin's lymphoma among heterosexual adults in the San Francisco Bay area. American Journal of Epidemiology 150:375-389; 1999. McGrath MS, Shiramizu B, Herndier BG. Clonal HIV in the pathogenesis of AIDS-related lymphoma: Sequential Pathogenesis In Infectious Causes of Cancer-Targets for Intervention. Ed. James J. Goedert, Humana Press, Totowa, NJ pps. 231-242. 2000. Zenger E, Abbey NW, Weinstein MD, Gofman I, Millward C, Gascon R, Elbaggari A, Herndier BG, McGrath MS. Injection of human primary effusion lymphoma cells or associated macrophages into SCID mice causes murine lymphomas. Cancer Research 62:5536-42; 2002. Gascon RL, Narvaez AB, Zhang R, Kahn JO, Hecht FM, Herndier BG, McGrath MS. Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 cell apoptosis and CD4 cell depletion. JAIDS 30(2):146-153; 2002. Mack KD, Jin X, Kapp L, Wei R, Abbey NW, Elbaggari A, Liu Y, Herndier BG, McGrath MS. HIV insertions within and proximal to host cell genes are a common finding in AIDS-related diseased tissues containing high levels of HIV p24 antigen expression. JAIDS, 33(3):308-320, 2003. To receive a copy of any of these publications, please contact: Marla K. Johnson